Papum Pare district is an administrative district in the state of Arunachal Pradesh in India. As of 2011 it is the most populous district of Arunachal Pradesh (out of 16)

The district was formed in 1999 when it was split from Lower Subansiri district.

The district headquarters are located at Yupia. Papum Pare district occupies an area of 2,875 square kilometres (1,110 sq mi).The capital of the state is Itanagar, which is also located in Papum Pare.

The district is divided into two sub-divisions: Sagalee and Yupia Capital complex, which are further divided into 10 administrative circles, namely, Mengio, Leporiang, Sagalee, Toru, Kimin, Doimukh, Balijan, Tarasso, Naharlagun and Itanagar.

There are 3 Arunachal Pradesh Legislative Assembly constituencies located in this district: Itanagar, Doimukh and Sagalee. All of these are part of Arunachal West Lok Sabha constituency

According to the 2011 census Papum Pare district has a population of 176,385, roughly equal to the nation of Sao Tome and Principe. This gives it a ranking of 594th in India (out of a total of 640). The district has a population density of 51 inhabitants per square kilometre (130/sq mi) . Its population growth rate over the decade 2001–2011 was 44.57%. Papumpare has a sex ratio of 950 females for every 1000 males,and a literacy rate of 82.14%.

Papum Pare is inhabited by members of the Nyishi, who are traditionally followers of Donyi-Polo. Some members of the Nyishi tribe are followers of Christianity.

In 1978 Papum Pare district became home to the Itanagar Wildlife Sanctuary, which has an area of 140 km2 (54.1 sq mi).